The concomitant use of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors may possibly lead to a rise in methadone plasma concentrations, which could bring about most likely lethal respiratory depression. Furthermore, discontinuation of concomitantly used cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers could also lead to an in

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